Multiple responses after intraperitoneal injection of endotoxin in rats.
نویسندگان
چکیده
منابع مشابه
Distribution of 3-hydroxy fatty acids in tissues after intraperitoneal injection of endotoxin.
BACKGROUND 3-Hydroxy fatty acids (3-OH FAs) with 10- to 18-carbon chain lengths are constituents of the endotoxin [lipopolysaccharide (LPS)] of gram-negative bacteria. We investigated whether these FAs may be used as chemical markers in measuring endotoxin concentrations in mammalian tissue samples. METHODS We used gas-liquid chromatography-tandem mass spectrometry to measure 3-OH FAs in seru...
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Injection into rabbits of a consistently lethal dose of endotoxin regularly produced a rapid and sustained fall of complement levels and lowered the titers of antibody to endotoxin. Doses of endotoxin below the LD(50) lowered complement levels sporadically but not the titers of antibody to endotoxin. The possibility is discussed that complement may be involved in the mechanisms responsible for ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1991
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)39394-1